6DE7

Crystal Structure at 4.3 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Interdomain Stabilization 113C-429GCG in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22

6DE7 の概要

• エントリーDOI: 10.2210/pdb6de7/pdb
• 分子名称: Envelope glycoprotein gp160, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (15 entities in total)
• 機能のキーワード: hiv-1, sosip, disulfide, trimer, immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 180581.75

構造登録者

Gorman, J.,Kwong, P.D. (登録日: 2018-05-11, 公開日: 2018-06-06, 最終更新日: 2023-10-11)

• 主引用文献: Zhang, P.,Gorman, J.,Geng, H.,Liu, Q.,Lin, Y.,Tsybovsky, Y.,Go, E.P.,Dey, B.,Andine, T.,Kwon, A.,Patel, M.,Gururani, D.,Uddin, F.,Guzzo, C.,Cimbro, R.,Miao, H.,McKee, K.,Chuang, G.Y.,Martin, L.,Sironi, F.,Malnati, M.S.,Desaire, H.,Berger, E.A.,Mascola, J.R.,Dolan, M.A.,Kwong, P.D.,Lusso, P.; Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.; Cell Host Microbe, 23:832-844.e6, 2018; PubMed: 29902444; DOI: 10.1016/j.chom.2018.05.002

実験手法

X-RAY DIFFRACTION (4.123 Å)