6DE5

Mycobacterium tuberculosis Rv2671 complexed with beta-NADPH and 6-ethyl-5-{(3S)-3-[2-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine

6DE5 の概要

• エントリーDOI: 10.2210/pdb6de5/pdb
• 分子名称: riboflavin biosynthesis protein RibD, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-{(3S)-3-[2-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: dhfr, antifolates, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28840.37

構造登録者

Hajian, B.,Wright, D. (登録日: 2018-05-11, 公開日: 2018-05-23, 最終更新日: 2023-10-11)

• 主引用文献: Hajian, B.,Scocchera, E.,Shoen, C.,Krucinska, J.,Viswanathan, K.,G-Dayanandan, N.,Erlandsen, H.,Estrada, A.,Mikusova, K.,Kordulakova, J.,Cynamon, M.,Wright, D.; Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.; Cell Chem Biol, 26:781-791.e6, 2019; PubMed: 30930162; DOI: 10.1016/j.chembiol.2019.02.013

実験手法

X-RAY DIFFRACTION (2.3 Å)