6DDS

Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid

6DDS の概要

• エントリーDOI: 10.2210/pdb6dds/pdb
• 関連するPDBエントリー: 6DDP
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid, ... (7 entities in total)
• 機能のキーワード: dhfr, antifolate, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 75777.94

構造登録者

Hajian, B.,Wright, D.,Scocchera, E. (登録日: 2018-05-10, 公開日: 2018-05-23, 最終更新日: 2023-10-11)

• 主引用文献: Hajian, B.,Scocchera, E.,Shoen, C.,Krucinska, J.,Viswanathan, K.,G-Dayanandan, N.,Erlandsen, H.,Estrada, A.,Mikusova, K.,Kordulakova, J.,Cynamon, M.,Wright, D.; Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.; Cell Chem Biol, 26:781-791.e6, 2019; PubMed: 30930162; DOI: 10.1016/j.chembiol.2019.02.013

実験手法

X-RAY DIFFRACTION (1.72 Å)