6DDJ

Crystal Structure of the human BRD2 BD2 bromodimain in complex with a Tetrahydroquinoline analogue

Summary for 6DDJ

• Entry DOI: 10.2210/pdb6ddj/pdb
• Descriptor: Bromodomain-containing protein 2, 4-{[(2S,4R)-1-acetyl-2-methyl-6-(1H-pyrazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]amino}benzonitrile, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bet, brd2, bromodomain, inhibitor, complex, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 14206.25

Authors

White, S.W.,Yun, M. (deposition date: 2018-05-10, release date: 2019-11-13, Last modification date: 2023-10-11)

• Primary citation: Slavish, P.J.,Chi, L.,Yun, M.K.,Tsurkan, L.,Martinez, N.E.,Jonchere, B.,Chai, S.C.,Connelly, M.,Waddell, M.B.,Das, S.,Neale, G.,Li, Z.,Shadrick, W.R.,Olsen, R.R.,Freeman, K.W.,Low, J.A.,Price, J.E.,Young, B.M.,Bharatham, N.,Boyd, V.A.,Yang, J.,Lee, R.E.,Morfouace, M.,Roussel, M.F.,Chen, T.,Savic, D.,Guy, R.K.,White, S.W.,Shelat, A.A.,Potter, P.M.; Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.; Cancer Res., 80:3507-3518, 2020; PubMed: 32651255; DOI: 10.1158/0008-5472.CAN-19-3934

Experimental method

X-RAY DIFFRACTION (1.05 Å)