6DDI

Crystal Structure of the human BRD2 BD1 bromodomain in complex with a Tetrahydroquinoline analogue

Summary for 6DDI

Entry DOI	10.2210/pdb6ddi/pdb
Descriptor	Bromodomain-containing protein 2, 4-{[(2S,4R)-1-acetyl-2-methyl-6-(1H-pyrazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]amino}benzonitrile, SULFATE ION, ... (6 entities in total)
Functional Keywords	bet, brd2, bromodomain, inhibitor, complex, transcription, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	49945.17
Authors	White, S.W.,Yun, M. (deposition date: 2018-05-10, release date: 2019-11-13, Last modification date: 2023-10-11)
Primary citation	Slavish, P.J.,Chi, L.,Yun, M.K.,Tsurkan, L.,Martinez, N.E.,Jonchere, B.,Chai, S.C.,Connelly, M.,Waddell, M.B.,Das, S.,Neale, G.,Li, Z.,Shadrick, W.R.,Olsen, R.R.,Freeman, K.W.,Low, J.A.,Price, J.E.,Young, B.M.,Bharatham, N.,Boyd, V.A.,Yang, J.,Lee, R.E.,Morfouace, M.,Roussel, M.F.,Chen, T.,Savic, D.,Guy, R.K.,White, S.W.,Shelat, A.A.,Potter, P.M. Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer. Cancer Res., 80:3507-3518, 2020 Cited by PubMed: 32651255 DOI: 10.1158/0008-5472.CAN-19-3934 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation