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6DCX

iASPP-PP-1c structure and targeting of p53

Summary for 6DCX
Entry DOI10.2210/pdb6dcx/pdb
DescriptorSerine/threonine-protein phosphatase PP1-alpha catalytic subunit, RelA-associated inhibitor (2 entities in total)
Functional Keywordsiaspp, aspp2, pp-1c, p53, ank repeats, rvxf motif, dephosphorylation, sh3, hydrolase-transcription complex, hydrolase/transcription
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight126827.57
Authors
Glover, J.N.M.,Zhou, Y.,Edwards, R.A. (deposition date: 2018-05-08, release date: 2019-05-15, Last modification date: 2023-10-11)
Primary citationZhou, Y.,Millott, R.,Kim, H.J.,Peng, S.,Edwards, R.A.,Skene-Arnold, T.,Hammel, M.,Lees-Miller, S.P.,Tainer, J.A.,Holmes, C.F.B.,Glover, J.N.M.
Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
Structure, 27:1485-1496.e4, 2019
Cited by
PubMed: 31402222
DOI: 10.1016/j.str.2019.07.012
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.408 Å)
Structure validation

217705

数据于2024-03-27公开中

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