6DCX
iASPP-PP-1c structure and targeting of p53
Summary for 6DCX
Entry DOI | 10.2210/pdb6dcx/pdb |
Descriptor | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, RelA-associated inhibitor (2 entities in total) |
Functional Keywords | iaspp, aspp2, pp-1c, p53, ank repeats, rvxf motif, dephosphorylation, sh3, hydrolase-transcription complex, hydrolase/transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 126827.57 |
Authors | Glover, J.N.M.,Zhou, Y.,Edwards, R.A. (deposition date: 2018-05-08, release date: 2019-05-15, Last modification date: 2023-10-11) |
Primary citation | Zhou, Y.,Millott, R.,Kim, H.J.,Peng, S.,Edwards, R.A.,Skene-Arnold, T.,Hammel, M.,Lees-Miller, S.P.,Tainer, J.A.,Holmes, C.F.B.,Glover, J.N.M. Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis. Structure, 27:1485-1496.e4, 2019 Cited by PubMed: 31402222DOI: 10.1016/j.str.2019.07.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.408 Å) |
Structure validation
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