6DCV

Crystal structure of human anti-tau antibody CBTAU-27.1

Summary for 6DCV

• Entry DOI: 10.2210/pdb6dcv/pdb
• Descriptor: Light chain of CBTAU27.1 Fab, heavy chain of CBTAU-27.1 Fab, GLYCEROL, ... (4 entities in total)
• Functional Keywords: tau, fab, naturally occurring human antibody, common motif, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 99085.97

Authors

Zhu, X.,Zhang, H.,Wilson, I.A. (deposition date: 2018-05-08, release date: 2018-06-06, Last modification date: 2023-10-11)

• Primary citation: Apetri, A.,Crespo, R.,Juraszek, J.,Pascual, G.,Janson, R.,Zhu, X.,Zhang, H.,Keogh, E.,Holland, T.,Wadia, J.,Verveen, H.,Siregar, B.,Mrosek, M.,Taggenbrock, R.,Ameijde, J.,Inganas, H.,van Winsen, M.,Koldijk, M.H.,Zuijdgeest, D.,Borgers, M.,Dockx, K.,Stoop, E.J.M.,Yu, W.,Brinkman-van der Linden, E.C.,Ummenthum, K.,van Kolen, K.,Mercken, M.,Steinbacher, S.,de Marco, D.,Hoozemans, J.J.,Wilson, I.A.,Koudstaal, W.,Goudsmit, J.; A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.; Acta Neuropathol Commun, 6:43-43, 2018; PubMed: 29855358; DOI: 10.1186/s40478-018-0543-z

Experimental method

X-RAY DIFFRACTION (1.9 Å)