6DCF

Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A

6DCF の概要

• エントリーDOI: 10.2210/pdb6dcf/pdb
• 分子名称: RNA polymerase-binding protein RbpA, SULFATE ION, ZINC ION, ... (15 entities in total)
• 機能のキーワード: inhibitor, complex, rna polymerase, transcription-dna-antibiotic complex, transcription/dna/antibiotic
• 由来する生物種: Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 447307.40

構造登録者

Lilic, M.,Darst, S.A.,Campbell, E.A. (登録日: 2018-05-06, 公開日: 2018-09-05, 最終更新日: 2023-10-11)

• 主引用文献: Peek, J.,Lilic, M.,Montiel, D.,Milshteyn, A.,Woodworth, I.,Biggins, J.B.,Ternei, M.A.,Calle, P.Y.,Danziger, M.,Warrier, T.,Saito, K.,Braffman, N.,Fay, A.,Glickman, M.S.,Darst, S.A.,Campbell, E.A.,Brady, S.F.; Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.; Nat Commun, 9:4147-4147, 2018; PubMed: 30297823; DOI: 10.1038/s41467-018-06587-2

実験手法

X-RAY DIFFRACTION (3.45 Å)