6DC1
Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 25 round 7
Summary for 6DC1
Entry DOI | 10.2210/pdb6dc1/pdb |
Descriptor | Kemp eliminase KE07, 5-nitro-2-oxidanyl-benzenecarbonitrile, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total) |
Functional Keywords | kemp eliminase, directed evolution, ke07, de novo protein, lyase |
Biological source | synthetic construct |
Total number of polymer chains | 12 |
Total formula weight | 351754.60 |
Authors | Jackson, C.J.,Hong, N.-S.,Carr, P.D. (deposition date: 2018-05-03, release date: 2018-08-01, Last modification date: 2023-10-04) |
Primary citation | Hong, N.S.,Petrovic, D.,Lee, R.,Gryn'ova, G.,Purg, M.,Saunders, J.,Bauer, P.,Carr, P.D.,Lin, C.Y.,Mabbitt, P.D.,Zhang, W.,Altamore, T.,Easton, C.,Coote, M.L.,Kamerlin, S.C.L.,Jackson, C.J. The evolution of multiple active site configurations in a designed enzyme. Nat Commun, 9:3900-3900, 2018 Cited by PubMed: 30254369DOI: 10.1038/s41467-018-06305-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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