6D9X
Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design
6D9X の概要
エントリーDOI | 10.2210/pdb6d9x/pdb |
分子名称 | WD repeat-containing protein 5, SODIUM ION, 2-phenyl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole, ... (4 entities in total) |
機能のキーワード | wdr5, win-site, fragment screening, structure-based design, mixed-lineage leukemia, dna binding protein, dna binding protein-inhibitor complex, dna binding protein/inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 34598.22 |
構造登録者 | |
主引用文献 | Wang, F.,Jeon, K.O.,Salovich, J.M.,Macdonald, J.D.,Alvarado, J.,Gogliotti, R.D.,Phan, J.,Olejniczak, E.T.,Sun, Q.,Wang, S.,Camper, D.,Yuh, J.P.,Shaw, J.G.,Sai, J.,Rossanese, O.W.,Tansey, W.P.,Stauffer, S.R.,Fesik, S.W. Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. J. Med. Chem., 61:5623-5642, 2018 Cited by PubMed: 29889518DOI: 10.1021/acs.jmedchem.8b00375 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.83 Å) |
構造検証レポート
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