6D5Y

Crystal structure of ERK2 G169D mutant

Summary for 6D5Y

Entry DOI	10.2210/pdb6d5y/pdb
Descriptor	Mitogen-activated protein kinase 1 (1 entity in total)
Functional Keywords	transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40533.63
Authors	Yin, J.,Jaiswal, B.S.,Wang, W. (deposition date: 2018-04-19, release date: 2019-02-27, Last modification date: 2024-03-13)
Primary citation	Jaiswal, B.S.,Durinck, S.,Stawiski, E.W.,Yin, J.,Wang, W.,Lin, E.,Moffat, J.,Martin, S.E.,Modrusan, Z.,Seshagiri, S. ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy. Clin. Cancer Res., 24:4044-4055, 2018 Cited by PubMed: 29760222 DOI: 10.1158/1078-0432.CCR-17-3674 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.86 Å)

Structure validation