6D5V

Ras:SOS:Ras in complex with a small molecule activator

6D5V の概要

分子名称GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... (7 entities in total)
機能のキーワードras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
由来する生物種Homo sapiens (Human)
ポリマー鎖数3
分子量合計95212.43
構造登録者
Phan, J.,Hodges, T.,Fesik, S.W. (登録日: 2018-04-19, 公開日: 2018-09-19, 最終更新日: 2018-11-07)
主引用文献
Hodges, T.R.,Abbott, J.R.,Little, A.J.,Sarkar, D.,Salovich, J.M.,Howes, J.E.,Akan, D.T.,Sai, J.,Arnold, A.L.,Browning, C.,Burns, M.C.,Sobolik, T.,Sun, Q.,Beesetty, Y.,Coker, J.A.,Scharn, D.,Stadtmueller, H.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,McConnell, D.B.,Fesik, S.W.
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61:8875-8894, 2018
PubMed: 30205005 (主引用文献が同じPDBエントリー)
DOI: 10.1021/acs.jmedchem.8b01108
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.04 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1875 0.4% 2.4% 2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード