6D49

Cell Surface Receptor in Complex with Ligand at 1.80-A Resolution

Summary for 6D49

• Entry DOI: 10.2210/pdb6d49/pdb
• Related: 6D48 6D4A
• Descriptor: Myeloid cell surface antigen CD33, GLYCEROL, 2-aminoethyl 5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->6)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, ... (4 entities in total)
• Functional Keywords: sialic acid binding, transmembrane, receptor, siglec, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 32071.41

Authors

Hermans, S.J.,Miles, L.A.,Parker, M.W. (deposition date: 2018-04-17, release date: 2019-04-17, Last modification date: 2023-10-04)

• Primary citation: Miles, L.A.,Hermans, S.J.,Crespi, G.A.N.,Gooi, J.H.,Doughty, L.,Nero, T.L.,Markulic, J.,Ebneth, A.,Wroblowski, B.,Oehlrich, D.,Trabanco, A.A.,Rives, M.L.,Royaux, I.,Hancock, N.C.,Parker, M.W.; Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis.; Iscience, 19:110-118, 2019; PubMed: 31369984; DOI: 10.1016/j.isci.2019.07.023

Experimental method

X-RAY DIFFRACTION (1.801 Å)