6D49

Cell Surface Receptor in Complex with Ligand at 1.80-A Resolution

Summary for 6D49

Related6D48 6D4A
DescriptorMyeloid cell surface antigen CD33, GLYCEROL, 2-aminoethyl 5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->6)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywordssialic acid binding, transmembrane, receptor, siglec, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight32071.41
Authors
Hermans, S.J.,Miles, L.A.,Parker, M.W. (deposition date: 2018-04-17, release date: 2019-04-17)
Primary citation
Hermans, S.J.,Doughty, L.,Markulic, J.,Crespi, G.A.N.,Miles, L.A.,Parker, M.W.
Structural basis for the recognition of carbohydrates by the Alzheimer's disease risk factor CD33
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.801 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21160 0.9% 5.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 6d49
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Molmil generated image of 6d49
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6d49.pdb2.gz [27.53 KB])
Coordinate files for Biological unit (6d49.pdb1.gz [27.66 KB])