6D3X

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

Summary for 6D3X

Entry DOI	10.2210/pdb6d3x/pdb
Descriptor	Plasminogen, Trypsin inhibitor 1 (3 entities in total)
Functional Keywords	protease, sfti, complex, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	57245.95
Authors	Law, R.H.P.,Wu, G. (deposition date: 2018-04-17, release date: 2019-01-23, Last modification date: 2023-10-04)
Primary citation	Swedberg, J.E.,Wu, G.,Mahatmanto, T.,Durek, T.,Caradoc-Davies, T.T.,Whisstock, J.C.,Law, R.H.P.,Craik, D.J. Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma. J. Med. Chem., 62:552-560, 2019 Cited by PubMed: 30520638 DOI: 10.1021/acs.jmedchem.8b01139 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation