6D3E

PPARg LBD in Complex with SR1988

Summary for 6D3E

• Entry DOI: 10.2210/pdb6d3e/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, 1-[(2,4-difluorophenyl)methyl]-2,3-dimethyl-N-[(1R)-1-phenylpropyl]-1H-indole-5-carboxamide (3 entities in total)
• Functional Keywords: type 2 diabetes, nuclear receptor, drug discovery, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 64584.88

Authors

Frkic, R.L.,Bruning, J.B. (deposition date: 2018-04-15, release date: 2019-02-27, Last modification date: 2023-10-04)

• Primary citation: Frkic, R.L.,Chua, B.S.,Shin, Y.,Pascal, B.D.,Novick, S.J.,Kamenecka, T.M.,Griffin, P.R.,Bruning, J.B.; Structural and Dynamic Elucidation of a Non-acid PPARgammaPartial Agonist: SR1988.; Nucl Receptor Res, 5:-, 2018; PubMed: 30906767; DOI: 10.11131/2018/101350

Experimental method

X-RAY DIFFRACTION (2.395 Å)