6D35

Crystal structure of Xenopus Smoothened in complex with cholesterol

Summary for 6D35

Entry DOI	10.2210/pdb6d35/pdb
Descriptor	Smoothened,Soluble cytochrome b562,Smoothened, CHOLESTEROL (2 entities in total)
Functional Keywords	gpcr, hedgehog signaling, class frizzled, sterol, membrane protein
Biological source	Xenopus laevis (African clawed frog) More
Total number of polymer chains	1
Total formula weight	67955.42
Authors	Huang, P.,Zheng, S.,Kim, Y.,Kruse, A.C.,Salic, A. (deposition date: 2018-04-14, release date: 2018-05-23, Last modification date: 2023-10-04)
Primary citation	Huang, P.,Zheng, S.,Wierbowski, B.M.,Kim, Y.,Nedelcu, D.,Aravena, L.,Liu, J.,Kruse, A.C.,Salic, A. Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell, 174:312-324.e16, 2018 Cited by PubMed: 29804838 DOI: 10.1016/j.cell.2018.04.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.9 Å)

Structure validation