6D1L

Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects

6D1L の概要

• エントリーDOI: 10.2210/pdb6d1l/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase inhibitors, neuropathic pain, selenium, metalloenzymes, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30023.02

構造登録者

Peat, T.S.,Angeli, A.,di Cesare Mannelli, L.,Micheli, L.,Ghelardini, C.,Supuran, C.T. (登録日: 2018-04-12, 公開日: 2018-06-13, 最終更新日: 2023-10-04)

• 主引用文献: Angeli, A.,di Cesare Mannelli, L.,Lucarini, E.,Peat, T.S.,Ghelardini, C.,Supuran, C.T.; Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.; Eur J Med Chem, 154:210-219, 2018; PubMed: 29803994; DOI: 10.1016/j.ejmech.2018.05.026

実験手法

X-RAY DIFFRACTION (1.4 Å)