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6D1B

Crystal structure of NDM-1 complexed with compound 2

Summary for 6D1B
Entry DOI10.2210/pdb6d1b/pdb
DescriptorMetallo-beta-lactamase type 2, ZINC ION, [(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid, ... (5 entities in total)
Functional Keywordsbeta-lactamase, carbapenemase, phosphonate, inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceKlebsiella pneumoniae
Total number of polymer chains1
Total formula weight25121.76
Authors
Pemberton, O.A.,Chen, Y. (deposition date: 2018-04-11, release date: 2019-04-17, Last modification date: 2023-10-04)
Primary citationPemberton, O.A.,Jaishankar, P.,Akhtar, A.,Adams, J.L.,Shaw, L.N.,Renslo, A.R.,Chen, Y.
Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.
J.Med.Chem., 62:8480-8496, 2019
Cited by
PubMed: 31483651
DOI: 10.1021/acs.jmedchem.9b00728
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.25 Å)
Structure validation

217705

건을2024-03-27부터공개중

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