6D0M

Polymerase Eta post-insertion binary complex with cytarabine (AraC)

Summary for 6D0M

• Entry DOI: 10.2210/pdb6d0m/pdb
• Descriptor: DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*AP*CP*AP*GP*TP*GP*CP*T)-3'), DNA/RNA (5'-D(*AP*GP*CP*AP*CP*TP*GP*T)-R(P*(CAR))-3'), ... (5 entities in total)
• Functional Keywords: cytarabine, arac, dna damage, translesion, dna synthesis, dna replication, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 55132.06

Authors

Rechkoblit, O.,Aggarwal, A.K. (deposition date: 2018-04-10, release date: 2018-09-05, Last modification date: 2023-10-04)

• Primary citation: Rechkoblit, O.,Choudhury, J.R.,Buku, A.,Prakash, L.,Prakash, S.,Aggarwal, A.K.; Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.; Sci Rep, 8:12702-12702, 2018; PubMed: 30140014; DOI: 10.1038/s41598-018-30796-w

Experimental method

X-RAY DIFFRACTION (1.832 Å)