6D0M
Polymerase Eta post-insertion binary complex with cytarabine (AraC)
Summary for 6D0M
Entry DOI | 10.2210/pdb6d0m/pdb |
Descriptor | DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*AP*CP*AP*GP*TP*GP*CP*T)-3'), DNA/RNA (5'-D(*AP*GP*CP*AP*CP*TP*GP*T)-R(P*(CAR))-3'), ... (5 entities in total) |
Functional Keywords | cytarabine, arac, dna damage, translesion, dna synthesis, dna replication, transferase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 55132.06 |
Authors | Rechkoblit, O.,Aggarwal, A.K. (deposition date: 2018-04-10, release date: 2018-09-05, Last modification date: 2023-10-04) |
Primary citation | Rechkoblit, O.,Choudhury, J.R.,Buku, A.,Prakash, L.,Prakash, S.,Aggarwal, A.K. Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine. Sci Rep, 8:12702-12702, 2018 Cited by PubMed: 30140014DOI: 10.1038/s41598-018-30796-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.832 Å) |
Structure validation
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