6CZU

BRD4(BD1) complexed with 3219

6CZU の概要

• エントリーDOI: 10.2210/pdb6czu/pdb
• 分子名称: Bromodomain-containing protein 4, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-({4-[(1R)-1-hydroxyethyl]phenyl}methyl)pyridin-2(1H)-one, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: bromodomain, brd4, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16166.58

構造登録者

Lakshminarasimhan, D.,White, A.,Suto, R.K. (登録日: 2018-04-09, 公開日: 2018-09-26, 最終更新日: 2018-10-10)

• 主引用文献: Kharenko, O.A.,Patel, R.G.,Brown, S.D.,Calosing, C.,White, A.,Lakshminarasimhan, D.,Suto, R.K.,Duffy, B.C.,Kitchen, D.B.,McLure, K.G.,Hansen, H.C.,van der Horst, E.H.,Young, P.R.; Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine.; J. Med. Chem., 61:8202-8211, 2018; PubMed: 30165024; DOI: 10.1021/acs.jmedchem.8b00666

実験手法

X-RAY DIFFRACTION (1.47 Å)