6CZ5
Crystal structure of small molecule AMP-acrylamide covalently bound to DDX3 S228C
Summary for 6CZ5
Entry DOI | 10.2210/pdb6cz5/pdb |
Descriptor | ATP-dependent RNA helicase DDX3X, 5'-O-[(R)-hydroxy(propanoylamino)phosphoryl]adenosine (2 entities in total) |
Functional Keywords | inhibitor, dead-box protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 54512.55 |
Authors | Barkovich, K.J.,Moore, M.K.,Hu, Q.,Shokat, K.M. (deposition date: 2018-04-08, release date: 2018-08-08, Last modification date: 2023-10-04) |
Primary citation | Barkovich, K.J.,Moore, M.K.,Hu, Q.,Shokat, K.M. Chemical genetic inhibition of DEAD-box proteins using covalent complementarity. Nucleic Acids Res., 46:8689-8699, 2018 Cited by PubMed: 30102385DOI: 10.1093/nar/gky706 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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