6CYU
Crystal structure of CTX-M-14 S70G/N106S/D240G beta-lactamase in complex with hydrolyzed cefotaxime
Summary for 6CYU
Entry DOI | 10.2210/pdb6cyu/pdb |
Related | 6CYQ |
Descriptor | Beta-lactamase, (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro -2H-1,3-thiazine-4-carboxylic acid (3 entities in total) |
Functional Keywords | beta-lactamase ctx-m-14, hydrolase-hydrolase inhibitor complex, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 28298.89 |
Authors | Patel, M.P.,Hu, L.,Sankaran, B.,Brown, C.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2018-04-06, release date: 2018-10-10, Last modification date: 2023-10-04) |
Primary citation | Patel, M.P.,Hu, L.,Brown, C.A.,Sun, Z.,Adamski, C.J.,Stojanoski, V.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. Synergistic effects of functionally distinct substitutions in beta-lactamase variants shed light on the evolution of bacterial drug resistance. J. Biol. Chem., 293:17971-17984, 2018 Cited by PubMed: 30275013DOI: 10.1074/jbc.RA118.003792 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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