6CYG

Hsp90-alpha N-domain bound to NEOCA

Summary for 6CYG

Entry DOI	10.2210/pdb6cyg/pdb
Descriptor	Heat shock protein HSP 90-alpha, 5'-N-(2-HYDROXYL)ETHYL CARBOXYAMIDO ADENOSINE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	hsp90, inhibitor, chaperone, chaperone-inhibitor complex, chaperone/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	57919.19
Authors	Huck, J.D.,Campomizzi, C.,Gewirth, D.T. (deposition date: 2018-04-05, release date: 2019-04-10, Last modification date: 2023-10-04)
Primary citation	Huck, J.D.,Que, N.L.S.,Immormino, R.M.,Shrestha, L.,Taldone, T.,Chiosis, G.,Gewirth, D.T. NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90. J.Biol.Chem., 294:16010-16019, 2019 Cited by PubMed: 31501246 DOI: 10.1074/jbc.RA119.009960 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.50392199595 Å)

Structure validation