6CYF

PcrV fragment with bound Fab

Summary for 6CYF

• Entry DOI: 10.2210/pdb6cyf/pdb
• Descriptor: Type III secretion system protein, IgG1 antibody, kappa light chain, IgG1 antibody, heavy chain fragment, ... (4 entities in total)
• Functional Keywords: part of type 3 secretion system in pseudomonas aeruginosa, immune system
• Biological source: Pseudomonas aeruginosa; More
• Total number of polymer chains: 12
• Total formula weight: 246318.54

Authors

Oganesyan, V. (deposition date: 2018-04-05, release date: 2018-08-01, Last modification date: 2024-10-30)

Primary citation

Tabor, D.E.,Oganesyan, V.,Keller, A.E.,Yu, L.,McLaughlin, R.E.,Song, E.,Warrener, P.,Rosenthal, K.,Esser, M.,Qi, Y.,Ruzin, A.,Stover, C.K.,DiGiandomenico, A.
Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Antibody MEDI3902, Are Conserved Among Diverse Global Clinical Isolates.
J. Infect. Dis., 218:1983-1994, 2018

PubMed Abstract: Bispecific antibody MEDI3902, targeting the Pseudomonas aeruginosa type 3 secretion system (PcrV) and Psl exopolysaccharide, is currently in phase 2b development for prevention of nosocomial pneumonia in patients undergoing mechanical ventilation. We surveyed a diverse collection of isolates to study MEDI3902 epitope conservation and protective activity.

PubMed: 30016475
DOI: 10.1093/infdis/jiy438

Experimental method

X-RAY DIFFRACTION (2.78 Å)