6CY7
Human Stimulator of Interferon Genes
Summary for 6CY7
Entry DOI | 10.2210/pdb6cy7/pdb |
Descriptor | Stimulator of interferon genes protein, (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, IMIDAZOLE, ... (5 entities in total) |
Functional Keywords | human sting, complex, cyclic-di-amp, tmem173, ala230 allelle, 230a/232r, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 27957.21 |
Authors | Fernandez, D.,Li, L.,Ergun, S.L. (deposition date: 2018-04-04, release date: 2019-03-13, Last modification date: 2023-10-04) |
Primary citation | Ergun, S.L.,Fernandez, D.,Weiss, T.M.,Li, L. STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition. Cell, 178:290-301.e10, 2019 Cited by PubMed: 31230712DOI: 10.1016/j.cell.2019.05.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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