6CX0

Structure of AtTPC1 D376A

6CX0 の概要

• エントリーDOI: 10.2210/pdb6cx0/pdb
• 分子名称: Two pore calcium channel protein 1, CALCIUM ION, (1S,3R)-1-(3-{[4-(2-fluorophenyl)piperazin-1-yl]methyl}-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid (3 entities in total)
• 機能のキーワード: ion channel, two-pore channel, tpc1, resting-state, closed, inactive, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor
• 由来する生物種: Arabidopsis thaliana (Mouse-ear cress)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 85025.21

構造登録者

Kintzer, A.F.,Stroud, R.M. (登録日: 2018-04-02, 公開日: 2018-09-19, 最終更新日: 2023-10-04)

• 主引用文献: Kintzer, A.F.,Green, E.M.,Dominik, P.K.,Bridges, M.,Armache, J.P.,Deneka, D.,Kim, S.S.,Hubbell, W.,Kossiakoff, A.A.,Cheng, Y.,Stroud, R.M.; Structural basis for activation of voltage sensor domains in an ion channel TPC1.; Proc. Natl. Acad. Sci. U.S.A., 115:E9095-E9104, 2018; PubMed: 30190435; DOI: 10.1073/pnas.1805651115

実験手法

X-RAY DIFFRACTION (3.501 Å)