6CUX

Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A

6CUX の概要

• エントリーDOI: 10.2210/pdb6cux/pdb
• 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (8 entities in total)
• 機能のキーワード: bacterial rna polymerase, kanglemycin a, transcription inhibitor, transcription, transcription-transcription inhibitor complex, transcription-antibiotic complex, transcription/antibiotic
• 由来する生物種: Escherichia coli (strain K12); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 921162.07

構造登録者

Molodtsov, V.,Murakami, K.S. (登録日: 2018-03-26, 公開日: 2018-07-25, 最終更新日: 2020-01-01)

• 主引用文献: Mosaei, H.,Molodtsov, V.,Kepplinger, B.,Harbottle, J.,Moon, C.W.,Jeeves, R.E.,Ceccaroni, L.,Shin, Y.,Morton-Laing, S.,Marrs, E.C.L.,Wills, C.,Clegg, W.,Yuzenkova, Y.,Perry, J.D.,Bacon, J.,Errington, J.,Allenby, N.E.E.,Hall, M.J.,Murakami, K.S.,Zenkin, N.; Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.; Mol. Cell, 72:263-274.e5, 2018; PubMed: 30244835; DOI: 10.1016/j.molcel.2018.08.028

実験手法

X-RAY DIFFRACTION (4.104 Å)