6CUR
Ras:SOS:Ras in complex with a small molecule activator
Summary for 6CUR
Entry DOI | 10.2210/pdb6cur/pdb |
Descriptor | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total) |
Functional Keywords | ras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 95845.94 |
Authors | Phan, J.,Abbott, J.,Fesik, S.W. (deposition date: 2018-03-26, release date: 2019-02-06, Last modification date: 2023-11-15) |
Primary citation | Abbott, J.R.,Patel, P.A.,Howes, J.E.,Akan, D.T.,Kennedy, J.P.,Burns, M.C.,Browning, C.F.,Sun, Q.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,Fesik, S.W. Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS. ACS Med Chem Lett, 9:941-946, 2018 Cited by PubMed: 30258545DOI: 10.1021/acsmedchemlett.8b00296 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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