6CUP

Ras:SOS:Ras in complex with a small molecule activator

6CUP の概要

分子名称GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total)
機能のキーワードras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
由来する生物種Homo sapiens (Human)
ポリマー鎖数3
分子量合計95764.82
構造登録者
Phan, J.,Abbott, J.,Fesik, S.W. (登録日: 2018-03-26, 公開日: 2019-02-06)
主引用文献
Abbott, J.R.,Patel, P.A.,Howes, J.E.,Akan, D.T.,Kennedy, J.P.,Burns, M.C.,Browning, C.F.,Sun, Q.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,Fesik, S.W.
Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
ACS Med Chem Lett, 9:941-946, 2018
PubMed: 30258545 (主引用文献が同じPDBエントリー)
DOI: 10.1021/acsmedchemlett.8b00296
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.833 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1743 0.3% 1.8% 2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード