6CTX
Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CBr2, beta, gamma dCTP analogue
Summary for 6CTX
Entry DOI | 10.2210/pdb6ctx/pdb |
Descriptor | DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(2DA))-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... (10 entities in total) |
Functional Keywords | dna polymerase beta, conformational change, enzyme mechanism, lfer, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 48816.16 |
Authors | Batra, V.K.,Wilson, S.H. (deposition date: 2018-03-23, release date: 2018-06-20, Last modification date: 2023-10-04) |
Primary citation | Batra, V.K.,Oertell, K.,Beard, W.A.,Kashemirov, B.A.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H. Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry, 57:3934-3944, 2018 Cited by PubMed: 29874056DOI: 10.1021/acs.biochem.8b00418 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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