Summary for 6CT7
| Descriptor | BIIB054 Fab light chain, BIIB054 Fab heavy chain, ACE-MET-ASP-VAL-PHE-MET-LYS-GLY-LEU-SER-LYS, ... (5 entities in total) |
|---|---|
| Functional Keywords | fab, complex, a-synuclein, parkinson disease, immune system |
| Biological source | Homo sapiens |
| Total number of polymer chains | 6 |
| Total molecular weight | 95024.07 |
| Authors | Arndt, J.W. (deposition date: 2018-03-22, release date: 2018-12-19, Last modification date: 2018-12-26) |
| Primary citation | Weihofen, A.,Liu, Y.,Arndt, J.W.,Huy, C.,Quan, C.,Smith, B.A.,Baeriswyl, J.L.,Cavegn, N.,Senn, L.,Su, L.,Marsh, G.,Auluck, P.K.,Montrasio, F.,Nitsch, R.M.,Hirst, W.D.,Cedarbaum, J.M.,Pepinsky, R.B.,Grimm, J.,Weinreb, P.H. Development of an aggregate-selective, human-derived alpha-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models. Neurobiol. Dis., 124:276-288, 2018 PubMed: 30381260 (PDB entries with the same primary citation) DOI: 10.1016/j.nbd.2018.10.016  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (1.903 Å) |
