6CT7

Fab of anti-a-synuclein antibody BIIB054 in complex with acetylated a-synuclein peptide (1-10)

Summary for 6CT7

DescriptorBIIB054 Fab light chain, BIIB054 Fab heavy chain, ACE-MET-ASP-VAL-PHE-MET-LYS-GLY-LEU-SER-LYS, ... (5 entities in total)
Functional Keywordsfab, complex, a-synuclein, parkinson disease, immune system
Biological sourceHomo sapiens
Total number of polymer chains6
Total molecular weight95024.07
Authors
Arndt, J.W. (deposition date: 2018-03-22, release date: 2018-12-19, Last modification date: 2018-12-26)
Primary citation
Weihofen, A.,Liu, Y.,Arndt, J.W.,Huy, C.,Quan, C.,Smith, B.A.,Baeriswyl, J.L.,Cavegn, N.,Senn, L.,Su, L.,Marsh, G.,Auluck, P.K.,Montrasio, F.,Nitsch, R.M.,Hirst, W.D.,Cedarbaum, J.M.,Pepinsky, R.B.,Grimm, J.,Weinreb, P.H.
Development of an aggregate-selective, human-derived alpha-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Neurobiol. Dis., 124:276-288, 2018
PubMed: 30381260 (PDB entries with the same primary citation)
DOI: 10.1016/j.nbd.2018.10.016
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.903 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22230 1.2% 1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution