6CT7

Fab of anti-a-synuclein antibody BIIB054 in complex with acetylated a-synuclein peptide (1-10)

6CT7 の概要

• エントリーDOI: 10.2210/pdb6ct7/pdb
• 分子名称: BIIB054 Fab light chain, BIIB054 Fab heavy chain, ACE-MET-ASP-VAL-PHE-MET-LYS-GLY-LEU-SER-LYS, ... (5 entities in total)
• 機能のキーワード: fab, complex, a-synuclein, parkinson disease, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 95024.07

構造登録者

Arndt, J.W. (登録日: 2018-03-22, 公開日: 2018-12-19, 最終更新日: 2018-12-26)

• 主引用文献: Weihofen, A.,Liu, Y.,Arndt, J.W.,Huy, C.,Quan, C.,Smith, B.A.,Baeriswyl, J.L.,Cavegn, N.,Senn, L.,Su, L.,Marsh, G.,Auluck, P.K.,Montrasio, F.,Nitsch, R.M.,Hirst, W.D.,Cedarbaum, J.M.,Pepinsky, R.B.,Grimm, J.,Weinreb, P.H.; Development of an aggregate-selective, human-derived alpha-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.; Neurobiol. Dis., 124:276-288, 2018; PubMed: 30381260; DOI: 10.1016/j.nbd.2018.10.016

実験手法

X-RAY DIFFRACTION (1.903 Å)