6CSB

V308E mutant of cytochrome P450 2D6 complexed with thioridazine

6CSB の概要

• エントリーDOI: 10.2210/pdb6csb/pdb
• 分子名称: Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, ... (8 entities in total)
• 機能のキーワード: conformational change proximal surface distal surface substrate binding c-d loop, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 222351.04

構造登録者

Yang, Y.T.,Fujita, K.,Wang, P.F.,Im, S.C.,Pearl, N.M.,Meagher, J.,Stuckey, J.,Waskell, L. (登録日: 2018-03-20, 公開日: 2019-03-27, 最終更新日: 2023-10-04)

• 主引用文献: Yang, Y.T.,Fujita, F.,Wang, P.F.,Im, S.C.,Pearl, N.M.,Meagher, J.,Stuckey, J.,Waskell, L.; Characteristic conformational changes on the distal and proximal surfaces of cytochrome P450 2D6 in response to substrate binding; To Be Published,

実験手法

X-RAY DIFFRACTION (2.394 Å)