6CQ5
TBK1 in Complex with Sulfone Analog of Amlexanox
Summary for 6CQ5
Entry DOI | 10.2210/pdb6cq5/pdb |
Descriptor | Serine/threonine-protein kinase TBK1, 2-amino-7-(1,1-dioxo-1lambda~6~-thian-4-yl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid (2 entities in total) |
Functional Keywords | tbk1, kinase, amlexanox, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 76414.32 |
Authors | Beyett, T.S.,Tesmer, J.J.G. (deposition date: 2018-03-14, release date: 2018-12-05, Last modification date: 2023-10-04) |
Primary citation | Beyett, T.S.,Gan, X.,Reilly, S.M.,Gomez, A.V.,Chang, L.,Tesmer, J.J.G.,Saltiel, A.R.,Showalter, H.D. Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity. Bioorg. Med. Chem., 26:5443-5461, 2018 Cited by PubMed: 30270002DOI: 10.1016/j.bmc.2018.09.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.354 Å) |
Structure validation
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