6CQ4

TBK1 in Complex with Cyclohexyl Analog of Amlexanox

6CQ4 の概要

• エントリーDOI: 10.2210/pdb6cq4/pdb
• 分子名称: Serine/threonine-protein kinase TBK1, 2-amino-7-(4,4-difluorocyclohexyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid (2 entities in total)
• 機能のキーワード: tbk1, kinase, amlexanox, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 76400.26

構造登録者

Beyett, T.S.,Tesmer, J.J.G. (登録日: 2018-03-14, 公開日: 2018-12-05, 最終更新日: 2023-10-04)

• 主引用文献: Beyett, T.S.,Gan, X.,Reilly, S.M.,Gomez, A.V.,Chang, L.,Tesmer, J.J.G.,Saltiel, A.R.,Showalter, H.D.; Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.; Bioorg. Med. Chem., 26:5443-5461, 2018; PubMed: 30270002; DOI: 10.1016/j.bmc.2018.09.020

実験手法

X-RAY DIFFRACTION (3.2 Å)