6CNU
Crystal Structure of JzTX-V
Summary for 6CNU
Entry DOI | 10.2210/pdb6cnu/pdb |
Descriptor | JzTx-V(D), JzTx-V, BROMIDE ION, ... (6 entities in total) |
Functional Keywords | inhibitor cysteine knot, toxin |
Biological source | Chilobrachys guangxiensis (Chinese earth tiger tarantula) More |
Total number of polymer chains | 2 |
Total formula weight | 7852.69 |
Authors | |
Primary citation | Wu, B.,Murray, J.K.,Andrews, K.L.,Sham, K.,Long, J.,Aral, J.,Ligutti, J.,Amagasu, S.,Liu, D.,Zou, A.,Min, X.,Wang, Z.,Ilch, C.P.,Kornecook, T.J.,Lin, M.J.,Be, X.,Miranda, L.P.,Moyer, B.D.,Biswas, K. Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis. J. Med. Chem., 61:9500-9512, 2018 Cited by PubMed: 30346167DOI: 10.1021/acs.jmedchem.8b00736 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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