6CMQ
Structure of human SHP2 without N-SH2 domain
Summary for 6CMQ
| Entry DOI | 10.2210/pdb6cmq/pdb |
| Descriptor | Tyrosine-protein phosphatase non-receptor type 11 (2 entities in total) |
| Functional Keywords | protein tyrosine phosphatase, src homology domain 2, open state, active mutant, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 196525.95 |
| Authors | Padua, R.A.P.,Sun, Y.,Marko, I.,Pitsawong, W.,Kern, D. (deposition date: 2018-03-06, release date: 2018-11-14, Last modification date: 2023-10-04) |
| Primary citation | Padua, R.A.P.,Sun, Y.,Marko, I.,Pitsawong, W.,Stiller, J.B.,Otten, R.,Kern, D. Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9:4507-4507, 2018 Cited by PubMed: 30375376DOI: 10.1038/s41467-018-06814-w PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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