6CKI

Co-crystal structure of MNK2 in Complex With Inhibitor

6CKI の概要

• エントリーDOI: 10.2210/pdb6cki/pdb
• 関連するPDBエントリー: 6cj5
• 分子名称: MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION, 3,3-dimethyl-6-[(pyrimidin-4-yl)amino]-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione, ... (4 entities in total)
• 機能のキーワード: mnk2, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 2: Nucleus, PML body. Isoform 1: Cytoplasm: Q9HBH9
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35941.15

構造登録者

Han, Q. (登録日: 2018-02-28, 公開日: 2018-05-09)

• 主引用文献: Reich, S.H.,Sprengeler, P.A.,Chiang, G.G.,Appleman, J.R.,Chen, J.,Clarine, J.,Eam, B.,Ernst, J.T.,Han, Q.,Goel, V.K.,Han, E.Z.R.,Huang, V.,Hung, I.N.J.,Jemison, A.,Jessen, K.A.,Molter, J.,Murphy, D.,Neal, M.,Parker, G.S.,Shaghafi, M.,Sperry, S.,Staunton, J.,Stumpf, C.R.,Thompson, P.A.,Tran, C.,Webber, S.E.,Wegerski, C.J.,Zheng, H.,Webster, K.R.; Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.; J. Med. Chem., 61:3516-3540, 2018; PubMed: 29526098; DOI: 10.1021/acs.jmedchem.7b01795

実験手法

X-RAY DIFFRACTION (2.95 Å)