6CJ2
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG056
6CJ2 の概要
エントリーDOI | 10.2210/pdb6cj2/pdb |
分子名称 | Bromodomain-containing protein 4, 2-{[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-5-methyl-11-(propan-2-yl)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one (3 entities in total) |
機能のキーワード | kinase, inhibitor, brd4, transcription, transcription-inhibitor complex, transcription/inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 15298.66 |
構造登録者 | |
主引用文献 | Wang, J.,Erazo, T.,Ferguson, F.M.,Buckley, D.L.,Gomez, N.,Munoz-Guardiola, P.,Dieguez-Martinez, N.,Deng, X.,Hao, M.,Massefski, W.,Fedorov, O.,Offei-Addo, N.K.,Park, P.M.,Dai, L.,DiBona, A.,Becht, K.,Kim, N.D.,McKeown, M.R.,Roberts, J.M.,Zhang, J.,Sim, T.,Alessi, D.R.,Bradner, J.E.,Lizcano, J.M.,Blacklow, S.C.,Qi, J.,Xu, X.,Gray, N.S. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. Acs Chem.Biol., 13:2438-2448, 2018 Cited by PubMed: 30102854DOI: 10.1021/acschembio.7b00638 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.47 Å) |
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