6CIR
Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 oxime
6CIR の概要
エントリーDOI | 10.2210/pdb6cir/pdb |
分子名称 | Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, 6-oxime-17-(3-pyridyl)-androst-16-en-3-ol, ... (4 entities in total) |
機能のキーワード | cytochrome p450, p450, cyp17a1, p450c17, p450 17a1, monooxygenase, 17a-hydroxylase, 17, 20-lyase, heme protein, cytochrome p450 oxidoreductase, membrane, microsome, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 226948.60 |
構造登録者 | |
主引用文献 | Fehl, C.,Vogt, C.D.,Yadav, R.,Li, K.,Scott, E.E.,Aube, J. Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2. J. Med. Chem., 61:4946-4960, 2018 Cited by PubMed: 29792703DOI: 10.1021/acs.jmedchem.8b00419 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.648 Å) |
構造検証レポート
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