6CIC

Structure of the human nitric oxide synthase R354A/G357D mutant heme domain in complex with N-(1-(2-(Ethyl(methyl)amino)ethyl)-1,2,3,4-tetrahydroquino-lin-6-yl)thiophene-2-carboximidamide

6CIC の概要

• エントリーDOI: 10.2210/pdb6cic/pdb
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100219.06

構造登録者

Li, H.,Poulos, T.L. (登録日: 2018-02-23, 公開日: 2018-10-31, 最終更新日: 2023-10-04)

• 主引用文献: Li, H.,Evenson, R.J.,Chreifi, G.,Silverman, R.B.,Poulos, T.L.; Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides.; Biochemistry, 57:6319-6325, 2018; PubMed: 30335983; DOI: 10.1021/acs.biochem.8b00895

実験手法

X-RAY DIFFRACTION (1.752 Å)