6CHF
Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 1)
Summary for 6CHF
Entry DOI | 10.2210/pdb6chf/pdb |
Descriptor | Uncharacterized protein DKFZp686C11235, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | immunoglobulin, igg1, immune system, immunoglobulin-like beta sandwich, fc fragment, lala mutation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 51225.28 |
Authors | Gohain, N.,Tolbert, W.D.,Pazgier, M. (deposition date: 2018-02-22, release date: 2019-02-27, Last modification date: 2023-10-04) |
Primary citation | Orlandi, C.,Deredge, D.,Ray, K.,Gohain, N.,Tolbert, W.,DeVico, A.L.,Wintrode, P.,Pazgier, M.,Lewis, G.K. Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fc gamma Receptor Binding. Structure, 2020 Cited by PubMed: 32209433DOI: 10.1016/j.str.2020.03.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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