6CG4
Covalently crosslinked trimer of a macrocyclic peptide derived from Abeta(17-36) - (ORN)LCVFFCED(ORN)AII(2-nitrobenzylglycine)L(ORN)V
Summary for 6CG4
Entry DOI | 10.2210/pdb6cg4/pdb |
Descriptor | ORN-CYS-VAL-PHE-PHE-CYS-GLU-ASP-ORN-ALA-ILE-ILE-EZY-LEU-ORN-VAL, IODIDE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total) |
Functional Keywords | amyloid, oligomer, alzheimer's disease, abeta, neuropeptide |
Biological source | synthetic construct |
Total number of polymer chains | 3 |
Total formula weight | 7106.03 |
Authors | Salveson, P.J.,Nowick, J.S. (deposition date: 2018-02-19, release date: 2018-05-16, Last modification date: 2020-01-01) |
Primary citation | Salveson, P.J.,Haerianardakani, S.,Thuy-Boun, A.,Kreutzer, A.G.,Nowick, J.S. Controlling the Oligomerization State of A beta-Derived Peptides with Light. J. Am. Chem. Soc., 140:5842-5852, 2018 Cited by PubMed: 29627987DOI: 10.1021/jacs.8b02658 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.083 Å) |
Structure validation
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