6CG4

Covalently crosslinked trimer of a macrocyclic peptide derived from Abeta(17-36) - (ORN)LCVFFCED(ORN)AII(2-nitrobenzylglycine)L(ORN)V

6CG4 の概要

• エントリーDOI: 10.2210/pdb6cg4/pdb
• 分子名称: ORN-CYS-VAL-PHE-PHE-CYS-GLU-ASP-ORN-ALA-ILE-ILE-EZY-LEU-ORN-VAL, IODIDE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
• 機能のキーワード: amyloid, oligomer, alzheimer's disease, abeta, neuropeptide
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 7106.03

構造登録者

Salveson, P.J.,Nowick, J.S. (登録日: 2018-02-19, 公開日: 2018-05-16, 最終更新日: 2020-01-01)

• 主引用文献: Salveson, P.J.,Haerianardakani, S.,Thuy-Boun, A.,Kreutzer, A.G.,Nowick, J.S.; Controlling the Oligomerization State of A beta-Derived Peptides with Light.; J. Am. Chem. Soc., 140:5842-5852, 2018; PubMed: 29627987; DOI: 10.1021/jacs.8b02658

実験手法

X-RAY DIFFRACTION (2.083 Å)