6CF7

Crystal structure of the A/Solomon Islands/3/2006(H1N1) influenza virus hemagglutinin in complex with small molecule JNJ4796

Summary for 6CF7

• Entry DOI: 10.2210/pdb6cf7/pdb
• Descriptor: Hemagglutinin, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: glycoprotein, ectodomain, n-glycosylation, viral protein
• Biological source: Influenza A virus (A/Solomon Islands/3/2006(H1N1)); More
• Total number of polymer chains: 2
• Total formula weight: 59322.77

Authors

Kadam, R.U.,Wilson, I.A. (deposition date: 2018-02-13, release date: 2019-02-13, Last modification date: 2023-10-04)

• Primary citation: van Dongen, M.J.P.,Kadam, R.U.,Juraszek, J.,Lawson, E.,Brandenburg, B.,Schmitz, F.,Schepens, W.B.G.,Stoops, B.,van Diepen, H.A.,Jongeneelen, M.,Tang, C.,Vermond, J.,van Eijgen-Obregoso Real, A.,Blokland, S.,Garg, D.,Yu, W.,Goutier, W.,Lanckacker, E.,Klap, J.M.,Peeters, D.C.G.,Wu, J.,Buyck, C.,Jonckers, T.H.M.,Roymans, D.,Roevens, P.,Vogels, R.,Koudstaal, W.,Friesen, R.H.E.,Raboisson, P.,Dhanak, D.,Goudsmit, J.,Wilson, I.A.; A small-molecule fusion inhibitor of influenza virus is orally active in mice.; Science, 363:-, 2019; PubMed: 30846569; DOI: 10.1126/science.aar6221

Experimental method

X-RAY DIFFRACTION (2.719 Å)