6CEH

Design, Synthesis, X-ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology

6CEH の概要

• エントリーDOI: 10.2210/pdb6ceh/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 4-[(prop-2-en-1-yl)selanyl]benzene-1-sulfonamide, ... (6 entities in total)
• 機能のキーワード: carbonic anhydrase inhibitors, diabetic pathology, organoselenium, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30059.92

構造登録者

Peat, T.S.,Angeli, A.,di Cesare Mannelli, L.,Trallori, E.,Ghelardini, C.,Carta, F.,Supuran, C.T. (登録日: 2018-02-11, 公開日: 2018-05-23, 最終更新日: 2023-10-04)

• 主引用文献: Angeli, A.,di Cesare Mannelli, L.,Trallori, E.,Peat, T.S.,Ghelardini, C.,Carta, F.,Supuran, C.T.; Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.; ACS Med Chem Lett, 9:462-467, 2018; PubMed: 29795760; DOI: 10.1021/acsmedchemlett.8b00076

実験手法

X-RAY DIFFRACTION (1.43 Å)