6CDY
Crystal structure of TEAD complexed with its inhibitor
Summary for 6CDY
Entry DOI | 10.2210/pdb6cdy/pdb |
Descriptor | Transcriptional enhancer factor TEF-4, 2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide (3 entities in total) |
Functional Keywords | transcription factor, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 55715.18 |
Authors | |
Primary citation | Li, Q.,Sun, Y.,Jarugumilli, G.K.,Liu, S.,Dang, K.,Cotton, J.L.,Xiol, J.,Chan, P.Y.,DeRan, M.,Ma, L.,Li, R.,Zhu, L.J.,Li, J.H.,Leiter, A.B.,Ip, Y.T.,Camargo, F.D.,Luo, X.,Johnson, R.L.,Wu, X.,Mao, J. Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. Cell Stem Cell, 26:675-692.e8, 2020 Cited by PubMed: 32259481DOI: 10.1016/j.stem.2020.03.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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