6CDY

Crystal structure of TEAD complexed with its inhibitor

6CDY の概要

• エントリーDOI: 10.2210/pdb6cdy/pdb
• 分子名称: Transcriptional enhancer factor TEF-4, 2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide (3 entities in total)
• 機能のキーワード: transcription factor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55715.18

構造登録者

LIU, S.,HAN, X.,LUO, X. (登録日: 2018-02-09, 公開日: 2020-07-01, 最終更新日: 2023-10-04)

• 主引用文献: Li, Q.,Sun, Y.,Jarugumilli, G.K.,Liu, S.,Dang, K.,Cotton, J.L.,Xiol, J.,Chan, P.Y.,DeRan, M.,Ma, L.,Li, R.,Zhu, L.J.,Li, J.H.,Leiter, A.B.,Ip, Y.T.,Camargo, F.D.,Luo, X.,Johnson, R.L.,Wu, X.,Mao, J.; Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.; Cell Stem Cell, 26:675-692.e8, 2020; PubMed: 32259481; DOI: 10.1016/j.stem.2020.03.002

実験手法

X-RAY DIFFRACTION (2.32 Å)